*co-first, #corresponding
Grimes lab members (bold): ^Postdoc, ^^Grad student, ^^^Undergraduate student
visualization and quantitation of spine deformity in zebrafish models of scoliosis by micro-computed tomography
EA Bearce^, BTB Ricamona, KH Fisher^^, JR O’Hara-Smith^^, DT Grimes#
STAR Protocols 4(4):102739
biallelic daw1 variants cause a motile ciliopathy characterized by laterality defects and subtle ciliary beating abnormalities
JS Leslie*, R Hjeij*, A Vivant*, EA Bearce^, L Dyer, J Wang, L Rawlins, J Kennedy, N Ubeyratna, J Fasham, ZH Irons^^, SB Craig^^^, J Koenig, S George, B Pode-Shakked, Y Bolkier, O Barel, S Mane, KK Frederiksen, O Wenger, E Scott, HE Cross, E Lorentzen, DP Norris, Y Anikster, H Omran, DT Grimes#, AH Crosby#, EL Baple#
Genetics in Medicine 24(11):2249-2261
On being the right shape: roles for cilia and cerebrospinal fluid flow in body and spine morphology
EA Bearce^#, DT Grimes#
Semin. Cell Dev. Biol. https://doi.og/10.1016/j.semcdv.2020.07.005
left-right asymmetric heart jogging increases the robustness of dextral heart looping in zebrafish
DT Grimes, VL Patterson, G Luna-Arvizu^^, J Schottenfeld-Roames, ZH Irons^^, RD Burdine
Dev. Biol. 459(2), 79-86 (2020)
ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model
RV Walker, JL Keynton, DT Grimes, V Sreekumar, DJ Williams, C Esapa, D Wu, MM Knight, DP Norris
Nat. Commun. 10, 1-11 (2019)
making and breaking symmetry in development, growth and disease
DT Grimes
Development 146, dev170985 (2019)
developmental biology: go with the flow to keep the body straight
DT Grimes
Curr. Biol. 29(3):R101-R103 (2019)
ZIP-5/bZIP transcription factor regulation of folate metabolism is critical for aging axon regeneration
V Lakhina, M McReynolds, DT Grimes, JD Rabinowitz, RD Burdine, CT Murphy
bioRxiv doi: https://doi.org/10.1101/727719
ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling
A Harris, P Siggers, S Corrochano, N Warr, D Sagar, DT Grimes, M Suzuki, RD Burdine, F Cong, B-K Koo, H Clevers, I Stevant, S Nef, S Wells, R Brauner, BB Rhouma, N Belguith, C Eozenou, J Bignon-Topalovic, A Bashamboo, K McElreavey#, Greenfield A#
PNAS 115(21):5474-9 (2018)
Modeling syndromic congenital heart defects in zebrafish
MG Grant*, VL Patterson*, DT Grimes, RD Burdine
Curr. Top. Dev Biol. 124:1-40 (2017)
Antagonistic interactions in the zebrafish midline prior to the emergence of asymmetric gene expression are important for left-right patterning
RD Burdine, DT Grimes
Phil. Trans. Royal Soc. B 371(1710):pii:2015402 (2016)
Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature
DT Grimes*, CW Boswell*, NFC Morante*, RM Henkelman, RD Burdine, B Ciruna
Science 352(6291):1341-44 (2016)
NIH Director's Blog | Wired | F1000 | Princeton Research | Neurosurgery
Genetic analysis reveals a hierarchy of interactions between Polycystin-encoding genes and genes controlling cilia function during left-right determination
DT Grimes, JL Keynton, MT Buenavista, X Jin, SH Patel, K Shinohara, J Vibert, DJ Williams, H Hamada, R Hussain, SM Nauli, DP Norris
Plos Genetics 12(6):e1006070 (2016)
c21orf59/kurly controls both cilia motility and polarization
K Jaffe*, DT Grimes*, J Schottenfeld-Roames*, ME Werner, T Ku, SK Kim, JL Pelliccia, NFC Morante, BJ Mitchell#, RD Burdine#
Cell Reports 14(8):1841-9 (2016)
ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis
P Goggolidou*, JL Stevens*, F Agueci, JL Keynton, G Wheway, DT Grimes, SH Patel, H Hilton, SK Morthorst, A DiPaolo, DJ Williams, J Sanderson, S Khoronenkova, N Powles-Glover, A Ermakov, C Esapa, R Romero, GL Dianov, J Briscoe, C Johnson, LB Pedersen, DP Norris
Development 141(20):2966-77 (2014)
Mouse models of ciliopathies: the state of the art
DP Norris, DT Grimes
Dis. Models Mech. 5(3):299-312 (2012)
Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway
VL Patterson, C Damrau, A Paudyal, B Reeve, DT Grimes, ME Stewart, DJ Williams, P Siggers, A Greenfield, JN Murdoch
Hum. Mol. Genet. 18(10):1719-39 (2009)
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